What is a trityl protecting group?
2 The triphenyl methyl (trityl) groups are frequently used as a protecting group for primary alcohols mainly in nucleoside and carbohydrate chemistry due to their significant stability during neutral/basic conditions and afford corresponding alcohols under mild acidic condition.
How do I get rid of trityl group?
The removal of the trityl group is carried out with the aid of mineral acids, Lewis acids (ZnCl2) or, most mildly, with silica gel.
What do protecting groups do?
Protecting groups are used in synthesis to temporarily mask the characteristic chemistry of a functional group because it interferes with another reaction. A good protecting group should be easy to put on, easy to remove and in high yielding reactions, and inert to the conditions of the reaction required.
Is Fmoc acid stable?
The Fmoc group is acid stable and Boc-Lys(Fmoc)-OH is used to prepare protected peptide fragments for fragment coupling.
What is protection and deprotection of functional groups?
The acetal is then called a protecting group for the carbonyl. After the step involving the hydride is complete, the acetal is removed (by reacting it with an aqueous acid), giving back the original carbonyl. This step is called deprotection.
What is the meaning of deprotection?
Noun. deprotection (countable and uncountable, plural deprotections) (chemistry) The removal of a protecting group when it is no longer needed.
What are the requirements for a protecting group?
A protecting group must fulfill a number of requirements: The protecting group reagent must react selectively (kinetic chemoselectivity) in good yield to give a protected substrate that is stable to the projected reactions. The protecting group must be selectively removed in good yield by readily available reagents.
What are orthogonal protecting groups?
Orthogonal protection is a strategy allowing the deprotection of multiple protective groups one at a time each with a dedicated set of reaction conditions without affecting the other.