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What is the life expectancy of LGS?

What is the life expectancy of LGS?

The characteristic diffuse slow spike wave pattern of LGS gradually disappears with age and is replaced by focal epileptic discharges, especially multiple independent spikes. Mortality rate is reported at 3% (mean follow-up period of 8.5 y) to 7% (mean follow-up period of 9.7 y). Death often is related to accidents.

Is Lennox-Gastaut syndrome curable?

There is no cure for the disorder. Complete recovery, including freedom from seizures and normal development, is very rare. The prognosis for individuals with Lennox-Gastaut syndrome varies. There is no cure for the disorder.

Is Lennox-Gastaut a rare disease?

Lennox-Gastaut syndrome affects an estimated 1 to 2 per million people. This condition accounts for less than 5 percent of all cases of childhood epilepsy. For unknown reasons, it appears to be more common in males than in females.

Is LGS a rare disease?

Lennox-Gastaut syndrome (LGS) is a rare and severe kind of epilepsy that starts in childhood. Children with LGS have seizures often, and they have several different kinds of seizures. This condition is hard to treat, but researchers are looking for new therapies.

What drug treats Lennox-Gastaut syndrome?

Valproate (valproic acid) is generally considered the first-line therapy for Lennox-Gastaut syndrome because it is effective against a wide spectrum of seizures.

Who discovered Lennox-Gastaut?

The prognosis for LGS is poor with a 5% mortality in childhood and persistent seizures into adulthood (80%–90%). LGS was named for neurologists William G. Lennox (Boston, USA) and Henri Gastaut (Marseille, France), who independently described the condition. The international LGS Awareness Day is on November 1.

How common is LGS?

Lennox-Gastaut syndrome (LGS) is a severe form of childhood epilepsy with multiple types of seizures. In 1 out of 4 people, no cause can be found. About 2 to 5% of children with epilepsy have LGS. Usually, LGS persists through childhood and adolescence to adult years.

What can I expect from Lennox-Gastaut syndrome?

Patients with LGS experience many different types of seizures including: Tonic – stiffening of the body. Atonic – temporary loss of muscle tone and consciousness, causing the patient to fall. Atypical absence – staring episodes.

What is Lennox-Gastaut syndrome?

Epilepsy causes sudden, intense bursts of electrical activity in the brain. Lennox-Gastaut syndrome (LGS) is a type of epilepsy. Patients with LGS experience many different types of seizures including: Tonic – stiffening of the body. Atonic – temporary loss of muscle tone and consciousness, causing the patient to fall.

How do you treat LGS?

The three main forms of treatment of Lennox-Gastaut syndrome are anti-epileptic drugs (AEDs), dietary therapy (typically the ketogenic diet) or device/surgery (VNS therapy or corpus callosotomy). Rarely, resective surgery is an option. Treatment may require the coordinated efforts of a team of specialists.

When was Lennox-Gastaut syndrome discovered?

LGS was described in 1966 by the Marseille School in France, where Gastaut et al. (1966) generously proposed the term Lennox syndrome to denote a childhood-onset epilepsy characterized by frequent tonic and absence seizures.

How long can you live with Lennox-Gastaut?

Their mean age was 23.0 ± 3.8 years (range 18.7–35.8 years) and the mean follow-up duration was 19.3 ± 6.0 years (range 8.3–32.5 years)….Clinical profiles.

Characteristics Values
12–60 months, n (%) 23 (33.8)
>60 months, n (%) 21 (30.9)
Brain MRI, n (%)
Normal 22 (32.4)