What is photosensitization example?
Photosensitization is a condition caused by the accumulation of a photodynamic agent in the skin that sensitizes it to ultraviolet radiation (Fowler 1993). Exposure of nonpigmented skin to UV radiation (e.g., the sun) results in dermatonecrosis.
What is a photosensitizer drug?
Photosensitizing agents are drugs that can make the skin more sensitive to UV radiation. Drug-induced phototoxic reactions generally present as unexpected sunburns or dermatitis on sun-exposed areas of the skin.
What is photosensitization reaction?
photosensitization, the process of initiating a reaction through the use of a substance capable of absorbing light and transferring the energy to the desired reactants.
What is the meaning of photodynamic therapy?
Photodynamic therapy (PDT) is a two-stage treatment that combines light energy with a drug (photosensitizer) designed to destroy cancerous and precancerous cells after light activation. Photosensitizers are activated by a specific wavelength of light energy, usually from a laser.
Is acetophenone a photosensitizer?
Acetophenone acts as a photosensitizer by absorbing light of wavelength greater than 300 nm and transfers the triplet energy of the state, so formed, to the thymine molecule via a collision process.
What is the purpose of photosensitizer?
Photosensitizers are molecules that can be activated by light in order to generate ROS that can damage cell structures from microorganisms or from diseased mammalian cells leading to cell death.
What are the photosensitizers used in photodynamic therapy?
Photosensitizers. Many photosensitizers for PDT exist. They divide into porphyrins, chlorins and dyes. Examples include aminolevulinic acid (ALA), Silicon Phthalocyanine Pc 4, m-tetrahydroxyphenylchlorin (mTHPC) and mono-L-aspartyl chlorin e6 (NPe6).
What is photosensitizer in photochemistry?
Photosensitizers are molecules which absorb light (hν) and transfer the energy from the incident light into another nearby molecule. This light is often within the visible spectrum or infrared spectrum, as any higher energy electromagnetic radiation may result in the photoelectric effect.
What are exogenous photosensitizers?
Exogenous photosensitizers are numerous and include many varieties of dyes and biomolecules; some are natural products, e.g., from plants, and many others have been produced synthetically for medical, agricultural, or other uses.
What drugs are used in photodynamic therapy?
What is PDT used for?
- Porfimer sodium (Photofrin) is a very widely used and studied photosensitizer. It’s activated by red light from a laser.
- Aminolevulinic acid (ALA or Levulan) is a drug that’s put right on the skin.
How is photodynamic therapy performed?
Photodynamic therapy uses a drug that is activated by light, called a photosensitizer or photosensitizing agent, to kill cancer cells. The light can come from a laser or other source, such as LEDs. Photodynamic therapy is also called PDT.