Is ezogabine still available?
Potiga (ezogabine, retigabine) is an anti-epileptic drug (AED) that was approved for seizure prevention by the U.S. Food and Drug Administration (FDA). The manufacturer discontinued this medication in 2017. Potiga was available in tablet form and was approved for adults ages 18 and over.
Is retigabine still used?
Production has been discontinued in June 2017. Retigabine works primarily as a potassium channel opener—that is, by activating a certain family of voltage-gated potassium channels in the brain.
Why was retigabine discontinued?
The company has stated the withdrawal is for commercial reasons, due to very limited use and declining numbers of patients initiating therapy on the drug.
Is ezogabine a controlled substance?
As such, DEA will schedule ezogabine as a controlled substance under the CSA. (3) Abuse of ezogabine may lead to limited physical dependence or psychological dependence relative to the drugs or other substances in Schedule IV.
Is retigabine approved?
On 10 June 2011, the FDA approved retigabine (USAN, ezogabine, Potiga®) for the adjunctive treatment of partial-onset seizures in patients aged 18 years and older [FDA, 2011].
How does retigabine work?
Retigabine has a novel mechanism of action for an antiseizure drug, acting as positive allosteric modulator of the neuronal potassium channels KNCQ (Kv2 to 5). Under normal physiologic conditions, KNCQ channels help establish the neuronal resting membrane potential, by providing a continual hyperpolarizing influence.
What schedule drug is ezogabine?
Ezogabine is subject to Schedules III-V security requirements and must be manufactured, distributed, and stored pursuant to 21 U.S.C.
What is another name for fycompa?
Perampanel (per AM pa nel) is the generic name (non-brand name) of a seizure medicine with the brand name Fycompa (fye COM puh). The name or look may be different in other countries. The dose (measured in milligrams, abbreviated “mg”) usually will be the same.
Is there a generic Vimpat?
Lacosamide (la-COS-a-mide) is the generic name (non-brand name) for the brand drug called Vimpat (VIM-pat) from UCB. It is available in tablet form, a liquid solution, and a liquid for injection. Lacosamide is available in many countries, but the name or look may be different.
What is Vimpat made of?
VIMPAT injection is a clear, colorless, sterile solution containing 10 mg lacosamide per mL for intravenous infusion. One 20-mL vial contains 200 mg of lacosamide drug substance. The inactive ingredients are sodium chloride and water for injection. Hydrochloric acid is used for pH adjustment.