Can congenital central hypoventilation syndrome cause death?

Can congenital central hypoventilation syndrome cause death?

Central Hypoventilation Syndrome (CHS) is a sleep-related breathing disorder that causes ineffective breathing, apnea, or respiratory arrest during sleep (and during wakefulness in severe cases). CHS can either be congenital (CCHS) or acquired (ACHS) later in life. The condition can be fatal if untreated.

What is a possible cause of Ondine’s curse?

The syndrome got its common name from an old German story, which was popularized by the 1811 novella “Udine” and later the 1938 play “Ondine.” According to legend, Ondine was a young nymph who fell in love with a mortal man. When she found out he was unfaithful to her, she became enraged and set a curse on him.

Can central hypoventilation syndrome be treated?

Treatment focuses on providing breathing support, usually through the use of a respirator, or ventilator. Some children with CCHS will need a ventilator 24 hours per day; others may only need breathing help when sleeping.

What is it called when you forget to breathe when awake?

What is apnea? Apnea is the medical term used to describe slowed or stopped breathing. Apnea can affect people of all ages, and the cause depends on the type of apnea you have.

Is there a condition where you forget to breathe?

Central sleep apnea is a sleep disorder in which you briefly stop breathing during sleep. Moments of apnea can occur repeatedly throughout the night as you sleep. The interruption of your breathing may indicate a problem with your brain’s signaling. Your brain momentarily “forgets” to tell your muscles to breathe.

Is Ondine’s curse curable?

Despite advances in diagnosis, treatment of Ondine’s curse continues to rely on respiratory support, with mechanical ventilation, and sometimes, tracheostomy, as the cornerstones of treatment.

Who discovered Ondine’s curse?

In 1962, Severinghaus and Mitchell coined the term Ondine’s curse to describe a syndrome that manifested in 3 adult patients after high cervical and brainstem surgery.

What is sleep related hypoventilation disorder?

Sleep-related hypoventilation is breathing that is not sufficient during sleep. Breathing is either too shallow or too slow. Sleep-related hypoventilation is a category of disorders that have different underlying causes. Overall, these disorders lead to an increase of carbon dioxide in the blood.

How rare is congenital central hypoventilation syndrome?

CCHS is a relatively rare disorder. More than 1,000 individuals with this condition have been identified.

Where is the PHOX2B gene located?

Paired-like homeobox 2b (PHOX2B), also known as neuroblastoma Phox (NBPhox), is a protein that in humans is encoded by the PHOX2B gene located on chromosome 4. It codes for a homeodomain transcription factor.